PXD077171-1

PXD077171 is an original dataset announced via ProteomeXchange.

Title	LiP-MS data analysis workflows with a hybrid LiP proteome benchmark
Description	To evaluate informatics workflows for DIA-based LiP-MS, we generated a high-quality benchmark data set comprising more than 170,000 LiP peptides with defined composition. We then performed comprehensive assessment of major DIA analysis platforms incorporating different spectral libraries, and introduced DIA-LiPQuan, an informatics pipeline tailored to DIA LiP-MS quantification and downstream analysis. Data re-analysis by DIA-LiPQuan with in silico libraries allows sensitive and robust detection of both site-specific structural remodeling of proteins and drug-bound protein targets from the cellular proteome. Collectively, our study provides a valuable benchmark resource and informatics package for LiP-MS data mining, which would facilitate its broader applications in structural proteomics and drug discovery.
HostingRepository	iProX
AnnounceDate	2026-04-14
AnnouncementXML	Submission_2026-04-15_01:22:07.783.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shanshan Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-15 01:21:38	ID requested
⏵ 1	2026-04-15 01:22:08	announced

Dataset with its publication pending

submitter keyword: LiP-MS

Wenqing Shui
contact affiliation	ShanghaiTech University
contact email	shuiwq@shanghaitech.edu.cn
lab head
Shanshan Li
contact affiliation	Shanghaitech University
contact email	lishsh@shanghaitech.edu.cn
dataset submitter

iProX dataset URI