⮝ Full datasets listing
PXD077122-1
PXD077122 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mutual interaction between Schwann cells and CD4+T cells promotes the progression of perineural invasion in colorectal cancer |
| Description | This study demonstrates that CD4+Tstr cells contribute to the formation of an immunosuppressive microenvironment. Furthermore, the high expression of TNFα by tumor cells in PNI tissues may promote Schwann cell release of CCL4 chemokine, thereby recruiting additional CD4+T cells and exacerbating PNI progression. Consequently, TNFα monoclonal antibodies may enhance the response to PD-1 monoclonal antibody therapy in patients with neuroinvasive colorectal cancer. |
| HostingRepository | iProX |
| AnnounceDate | 2026-04-14 |
| AnnouncementXML | Submission_2026-04-14_01:38:52.408.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Huayuan Liu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-04-14 01:37:09 | ID requested | |
| ⏵ 1 | 2026-04-14 01:38:52 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Schwann cells, CD4+Tstr cells, colorectal cancer, perineural invasion, mutual interaction |
Contact List
| Hong Zhao | |
|---|---|
| contact affiliation | Peking Union Medical College |
| contact email | 18392885502@163.com |
| lab head | |
| Huayuan Liu | |
| contact affiliation | Peking Union Medical College |
| contact email | 348814000@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
