PXD077095 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of major histocompatibility complex class I ligands in ovarian adenocarcinoma tumors |
| Description | BACKGROUND. For developing targeted immunotherapy against ovarian adenocarcinoma, direct identification of peptides presented by major histocompatibility complex class I (HLA I) on the surface of tumor cells can be utilized.
AIM. To identify ligands of HLA I of ovarian adenocarcinoma tumors.
METHODS. Immunopeptidome from postoperative material of patients with ovarian adenocarcinoma were isolated using immunoaffinity chromatography and analyzed by liquid chromatography-mass spectrometry.
RESULTS. Using NP-40, 5 peptides belonging to the proteins of cancer/testis antigens (CTA) were identified in the immunopeptidomes of postoperative material from patients with ovarian adenocarcinoma, 3 of which, according to the human protein atlas, are indeed not expressed in normal ovarian tissues.
CONCLUSION. Immunopeptidome analysis allows the identification of peptides of CTA proteins, but a larger sample of postoperative material from patients with ovarian adenocarcinoma and experimental testing of the immunogenicity of the identified peptides are needed for further research. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-15 |
| AnnouncementXML | Submission_2026-04-15_09:06:14.145.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD077095 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Georgij Arapidi |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-04-13 15:16:23 | ID requested | |
| 1 | 2026-04-15 09:00:31 | announced | |
| ⏵ 2 | 2026-04-15 09:06:14 | announced | 2026-04-15: Updated project metadata. |
Publication List
Keyword List
Contact List
| Georgij Arapidi |
|---|
| contact affiliation | Head of System Biology Lab. at Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency |
| contact email | arapidi@gmail.com |
| lab head | |
| Georgij Arapidi |
|---|
| contact affiliation | System Biology Lab. at Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency |
| contact email | arapidi@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD077095
- Label: PRIDE project
- Name: Identification of major histocompatibility complex class I ligands in ovarian adenocarcinoma tumors
