PXD076863 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Tripartite motif 46 aggravates MASLD progression by suppressing SGPL1- mediated hepatic lipophagy |
| Description | Protein post-translational modifications (PTMs) participate in important bioactive regulatory processes and therefore can help elucidate the pathogenesis of Metabolic dysfunction-associated steatotic liver disease (MASLD). Ubiquitination modification plays a vital role in regulating the inflammatory response and fibrosis in MASLD process. Here, we performed multi-omics analysis to demonstated that TRIM46 binds directedly with SGPL1, promoting SGPL1 degradation via K48-linked polyubiquitination which subsequently suppresses the activation of downstream lipophagy signaling cascades in MASLD progression. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-30 |
| AnnouncementXML | Submission_2026-05-30_02:49:19.096.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yaoyao Jin |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-04-10 03:36:44 | ID requested | |
| ⏵ 1 | 2026-05-30 02:49:19 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: MASLD |
| hepatocyteï¼›Ubiquitination |
| TRIM46; |
Contact List
| Junyong Wang |
|---|
| contact affiliation | State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cance, School of Convergence Medicine, Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, 450052, China. |
| contact email | wangjunyong@zzu.edu.cn |
| lab head | |
| Yaoyao Jin |
|---|
| contact affiliation | Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China; Center for Basic Medical Research, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China. |
| contact email | 18834893640@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD076863 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD076863
- Label: PRIDE project
- Name: Tripartite motif 46 aggravates MASLD progression by suppressing SGPL1- mediated hepatic lipophagy
