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PXD076839-1
PXD076839 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparison of proteins of Streptococcus suis wild-type and ΔmnmE mutant strains |
| Description | Streptococcus suis is one of the most important bacterial pathogens of pigs, it is also an important zoonotic pathogen. It can withstand environmental stress and respond rapidly to stress. However, the regulatory mechanisms involved in this process are not fully elucidated. MnmE is a multi-domain GTPase that is highly conserved in bacteria and eukaryotes, driving tRNA modification during translation. In this study, we constructed an mnmE deletion strain (ΔmnmE) and a complementary strain (CΔmnmE) using the wild-type strain 05ZYH33 of S. suis, and systematically studied the characteristics and functions of MnmE in S. suis through phenotypic and multi-omics analyses. Phenotypic analysis showed that the mnmE strain exhibited growth defects, reduced virulence, decreased environmental tolerance, reduced capacity for metal ion transport, and changes in protein synthesis capabilities. Multi-omics results indicated that cellular processes related to carbohydrate metabolism, transcription and translation, and inorganic ion transport and metabolism were affected, which corroborated the phenotypic analysis. |
| HostingRepository | iProX |
| AnnounceDate | 2026-04-09 |
| AnnouncementXML | Submission_2026-04-10_00:37:24.784.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuxuan Huang |
| SpeciesList | scientific name: Streptococcus suis 05ZYH33; NCBI TaxID: 391295; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-04-10 00:28:07 | ID requested | |
| ⏵ 1 | 2026-04-10 00:37:25 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Streptococcus suis, MnmE |
Contact List
| Gang Li | |
|---|---|
| contact affiliation | Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences |
| contact email | ligang@caas.cn |
| lab head | |
| Yuxuan Huang | |
| contact affiliation | Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences |
| contact email | 447276782@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
