PXD076786 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of HThPA-binding proteins |
| Description | Although copper ionophore can transport exogenous copper into cells for cuproptotic induction to treat cancers, one of critical problems is copper overload that leads to imbalance of physiological homeostasis and occurrence of various side-effects. For example, ES plus copper treatment in mice often causes a series of side effects, such as acute liver injury. An understanding on cuproptotic induction by physiological copper would be important. We found that HThPA can trigger cuproptosis depending on intracellular endogenous copper ions, but the specific molecular mechanism remains unclear. Therefore, we synthesized an HThPA probe, enriched HThPA-binding proteins via click chemistry, and combined this with the effects of knocking down candidate binding proteins on cell death to identify the targets of HThPA. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-25 |
| AnnouncementXML | Submission_2026-04-25_03:50:27.109.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kejun Xu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-04-09 12:55:42 | ID requested | |
| ⏵ 1 | 2026-04-25 03:50:27 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Nuclear receptor Nur77 |
| HThPA |
| Copper |
Contact List
| Kejun Xu |
|---|
| contact affiliation | State Key Laboratory of Cellular Stress Biology, Xiang’an Hospital, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian Province, P. R. China |
| contact email | 1329490903@qq.com |
| lab head | |
| Kejun Xu |
|---|
| contact affiliation | Xiamen University |
| contact email | 1329490903@qq.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD076786 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD076786
- Label: PRIDE project
- Name: Identification of HThPA-binding proteins
