PXD076672 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of copper-binding-induced polymeric protein complexes |
| Description | Cuproptosis is characterized by copper ion-induced polymerization of lipoylated proteins. Whether other proteins involved in cuprotosis also undergo polymerization in the presence of copper ions remains to be determined. In this study, we utilized three experimental approaches to identify novel copper-induced polymerized proteins associated with cuprotosis. In the first two approaches, melanoma A375 cells were treated with copper ionophores—either elesclomol (ES) or disulfiram (DSF) in combination with copper—prior to cell lysis. In the third approach, cell lysates were directly incubated with copper ions in vitro. The resulting lysates were then subjected to non-reducing gel electrophoresis to detect proteins that undergo copper-induced polymerization. We expect to identify new target proteins of copper ions and new participating and executing proteins of copper death through this method. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-25 |
| AnnouncementXML | Submission_2026-04-25_03:55:26.589.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kejun Xu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-04-07 04:20:52 | ID requested | |
| ⏵ 1 | 2026-04-25 03:55:27 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: cuproptosis |
| polymerization |
| Copper |
Contact List
| Kejun Xu |
|---|
| contact affiliation | State Key Laboratory of Cellular Stress Biology, Xiang’an Hospital, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian Province, P. R. China |
| contact email | 1329490903@qq.com |
| lab head | |
| Kejun Xu |
|---|
| contact affiliation | Xiamen University |
| contact email | 1329490903@qq.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD076672 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD076672
- Label: PRIDE project
- Name: Identification of copper-binding-induced polymeric protein complexes
