PXD076616 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic profile of hippocampal growth cones through early postnatal development |
| Description | During early postnatal development, hippocampal circuits are assembled through the coordinated navigation of axonal growth cones toward their synaptic targets. While growth cones are known to rely on local proteomic changes to interpret guidance cues, the developmental dynamics of their proteomic composition remain poorly understood. We performed a systematic proteomic characterization of growth cones isolated from whole Hippocampus or Dentate gyrus tissue at postnatal day (P) 1, 3, and 5 from wildtype animals. Our analysis showed that at P1 growth cones of both tissues have a common proteomic signature. While hippocampal growth cones undergo a rapid transition from exploratory to a more mature state until P5, growth cones of the Dentate Gyrus maintain their exploratory profile in the same time frame suggesting a delayed maturation. Growth cones of the Hippocampus and Dentate Gyrus are characterized by several temporally regulated proteins, reflecting their dynamicity and different developmental trajectories. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-11 |
| AnnouncementXML | Submission_2026-06-10_22:14:42.881.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Maike Krause |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | proteomics |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-04-05 14:47:56 | ID requested | |
| ⏵ 1 | 2026-06-10 22:14:43 | announced | |
Publication List
Keyword List
| submitter keyword: local translation, proteomics, hippocampus,Early Postnatal development, brain tissue, growth cones, transgenic mouse line, LC-MS/MS |
Contact List
| Giulia Quattrocolo |
|---|
| contact affiliation | Group Leader, Quattrocolo Lab, Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway |
| contact email | giulia.quattrocolo@ntnu.no |
| lab head | |
| Maike Krause |
|---|
| contact affiliation | Kavli Institute for Systems Neuroscience and Center for Neural Computation
Norwegian University of Science and Technology (NTNU)
Trondheim 7491 |
| contact email | maike.krause@ntnu.no |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD076616 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD076616
- Label: PRIDE project
- Name: Proteomic profile of hippocampal growth cones through early postnatal development
