⮝ Full datasets listing
PXD076347-2
PXD076347 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Activity Identification and Proteomics Analysis of Water-Soluble Proteins in Cocoon Coat from Different Silkworm Varieties |
| Description | This study established, for the first time, a system for extracting water-soluble active proteins from the cocoon layers of multiple pigmented silkworm varieties and systematically evaluated their consistent antioxidant activities together with variety-specific antimicrobial functions. DIA-based proteomics identified 462 catalytic and binding proteins, revealing compositional differences among the three varieties and demonstrating that active protein diversity underlies the observed divergence in antimicrobial efficacy. Differential protein analysis highlighted zonadhesin-like proteins as key components, with TIL domains predicted by AlphaFold 3 to form a unique convex loop-mediated interaction interface. This work provides the first evidence of high-abundance insect-derived zonadhesin-like proteins in the cocoon matrix, and although their functional roles remain uncharacterized, the finding establishes a novel direction for future mechanistic research. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-30 |
| AnnouncementXML | Submission_2026-05-12_00:28:36.349.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hao Tian |
| SpeciesList | scientific name: Bombyx mori; NCBI TaxID: 7091; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-31 01:03:48 | ID requested | |
| 1 | 2026-03-31 01:04:04 | announced | |
| ⏵ 2 | 2026-05-12 00:28:37 | announced | 2026-05-12: Add info |
Publication List
| Tian H, Chen W, Li J, Zhang Y, Cheng T, Zhang W, Liu C, Activity identification and proteomics analysis of water-soluble proteins in cocoon coat from different silkworm varieties. Insect Biochem Mol Biol, 192():104564(2026) [pubmed] |
Keyword List
| submitter keyword: Cocoon Coat, Proteomics, Water-Soluble Proteins, Antibacterial Activity, Zonadhesin, TIL |
Contact List
| Chun Liu | |
|---|---|
| contact affiliation | State Key Laboratory of Resource Insects, Southwest University |
| contact email | mlliuchun@163.com |
| lab head | |
| Hao Tian | |
| contact affiliation | State Key Laboratory of Resource Insects, Southwest University |
| contact email | th1330193124@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
