PXD076279 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Charting endocrine progenitors across species and organs |
| Description | Hormone-producing cells in the pancreas and intestine regulate whole-body metabolism and are key targets for causal therapies for diabetes and obesity. A deeper understanding of endocrine lineage formation (endocrinogenesis) in these organs is essential to elucidate disease mechanisms and develop improved therapies. Here, we performed cross-species (mouse-human) and cross-system (in vivo-in vitro) comparisons of pancreatic endocrine progenitors (EPs), complemented by cross-organ (pancreas-intestine) analyses, using single-cell transcriptomics and epigenomics integrated with bulk proteomics. We uncovered shared and distinct gene regulatory networks (GRNs) and cell-cell communication patterns during lineage allocation across species, systems, and organs. Additionally, we identified cardiometabolic risk-associated genes restricted to embryonic pancreatic EPs but largely absent in the adult pancreas, implicating developmental origins of disease. Furthermore, our integrated, multi-source EP profiling resolved the transcriptional programs underlying off-target enterochromaffin cell formation during in vitro differentiation toward human islet cells. Finally, we revealed conserved, dynamic shifts in programs governing the cell cycle, mRNA translation, and cytoskeletal organization during endocrinogenesis. Collectively, this multi-source EP profiling establishes a resource that charts the molecular landscape of endocrinogenesis and informs therapies for metabolic disease. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-25 |
| AnnouncementXML | Submission_2026-08-25_00:59:57.786.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Natalie Krahmer |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-27 17:44:22 | ID requested | |
| ⏵ 1 | 2026-08-25 00:59:58 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Diabetes, Ngn3,Pancreas, Proteomics, endocrine progenitor, β-cells |
Contact List
| Natalie Krahmer |
|---|
| contact affiliation | Emmy-Noether Research Group Cellular Proteomics and Metabolic Signaling Institute for Diabetes and Obesity Helmholtz Diabetes Center Germany |
| contact email | natalie.krahmer@helmholtz-muenchen.de |
| lab head | |
| Natalie Krahmer |
|---|
| contact affiliation | Helmholtz Center Munich |
| contact email | natalie.krahmer@helmholtz-muenchen.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD076279 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD076279
- Label: PRIDE project
- Name: Charting endocrine progenitors across species and organs
