PXD076243 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting 3-mercaptopyruvate sulfurtransferase induces cancer stem cell death |
| Description | 3-mercaptopyruvate sulfurtransferase (3-MST) is involved in hydrogen sulfide production and cellular metabolism. Here, we investigated its role in colorectal cancer stem cells (CSCs), a therapy-resistant population with reduced bioenergetic activity. Proteomic analyses were performed in HCT116 wild-type cells (WT), CSCs and Rescue cells generated by CSC re-differentiation. Inhibition of 3-MST induced a marked bioenergetic impairment and promoted CSC death. DIA-based proteomics revealed significant remodeling of metabolic pathways, including glycolysis, TCA cycle, and lipid metabolism, along with activation of stress and cell death pathways. This dataset provides a resource to study the metabolic role of 3-MST in CSCs. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-06_23:26:12.457.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Michael Stumpe |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-27 05:50:10 | ID requested | |
| ⏵ 1 | 2026-09-06 23:26:13 | announced | |
Publication List
Keyword List
Contact List
| Dieter Kressler |
|---|
| contact affiliation | Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland |
| contact email | dieter.kressler@unifr.ch |
| lab head | |
| Michael Stumpe |
|---|
| contact affiliation | Department of Biology,
University of Fribourg |
| contact email | michael.stumpe@unifr.ch |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD076243 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD076243
- Label: PRIDE project
- Name: Targeting 3-mercaptopyruvate sulfurtransferase induces cancer stem cell death
