PXD076155-1

PXD076155 is an original dataset announced via ProteomeXchange.

Title	Neutrophil proteomic changes associated with sepsis
Description	To identify potential targetable mechanisms controlling neutrophil degranulation in systemic infection, we investigated alterations in neutrophil developmental state under severe inflammation. We performed tandem mass tag (TMT) proteomics on neutrophils isolated from peripheral blood of sepsis patients. We collected blood from patients with septic shock at Bristol Royal Infirmary (United Kingdom, n = 4). For each patient group, we collected matched healthy controls (HC) from the same populations. We performed longitudinal sampling at days 1 (T1), 4 (T2), 10 (T3) and 25 (T4) post admission to intensive care.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-07_04:21:10.502.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Borko Amulic
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-25 11:29:43	ID requested
⏵ 1	2026-09-07 04:21:11	announced

Zakrzewski P, Rice CM, Naveh C, Dowell I, Fleming K, Ramesh AV, Jones R, Moura PL, Cela D, Groves S, Fletcher-Jones S, Victory Y, Bhima M, Ebmeier S, Carey L, Butler M, Satchell SC, Berg A, Palolite N, Nyirenda J, Nyasulu W, Zgambo I, Attipa C, Wooldridge L, Davidson AD, Cunnington A, Moxon CA, Amulic B, Mitochondrial activity promotes neutrophil degranulation and endothelial dysfunction in systemic infections. EMBO Mol Med, 18(7):2691-2722(2026) [pubmed]

10.1038/s44321-026-00453-1;

submitter keyword: sepsis,neutrophil

Borko Amulic
contact affiliation	School of Cellular and Molecular Medicine, University of Bristol
contact email	borko.amulic@bristol.ac.uk
lab head
Borko Amulic
contact affiliation	University of Bristol
contact email	borko.amulic@bristol.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD076155

PRIDE project URI

• PRIDE
  1. PXD076155
     1. Label: PRIDE project
     2. Name: Neutrophil proteomic changes associated with sepsis