PXD076137-2

PXD076137 is an original dataset announced via ProteomeXchange.

Title	SEPHS2 loss reprograms cancer metabolism from oxidative phosphorylation to gluconeogenesis via PCK1 stabilization
Description	SEPHS2, a key enzyme in synthesizing selenoproteins, which converts hydrogen selenide into selenophosphate. Here we provide the proteome of SEPHS2 knockout human A375 celllines.
HostingRepository	iProX
AnnounceDate	2026-03-25
AnnouncementXML	Submission_2026-05-12_00:29:57.354.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lingyun Dai
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-25 01:39:48	ID requested
1	2026-03-25 01:41:19	announced
⏵ 2	2026-05-12 00:29:58	announced	2026-05-12: Add info

Zhang Y, Zhang Q, Wei B, Wang W, Chen X, Ding W, Li C, Ye Y, Xu J, Zhang W, Li L, Mai F, He W, Du X, Zhao K, Zhao Z, Huang J, Niu Y, Zhang Y, Dai L, Zhang B, Xia S, SEPHS2 loss reprograms cancer metabolism from oxidative phosphorylation to gluconeogenesis via PCK1 stabilization. Cell Rep, 45(5):117297(2026) [pubmed]

submitter keyword: SEPHS2 loss reprograms cancer metabolism, oxidative phosphorylation, gluconeogenesis, PCK1 stabilization

Lingyun Dai
contact affiliation	the First Affiliated Hospital of Southern University of Science and Technology
contact email	lingyun.dai@outlook.com
lab head
Lingyun Dai
contact affiliation	the First Affiliated Hospital of Southern University of Science and Technology
contact email	lingyun.dai@outlook.com
dataset submitter

iProX dataset URI