PXD076119 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Systematic Analysis of Plasma-Derived Extracellular Vesicle-Enriched Samples in Age-Related Macular Degeneration Reveals Oxidative Stress Linked to Altered Lipid and Protein Profiles |
| Description | Vision impairment caused by age-related macular degeneration (AMD) is a global health priority. Retinal pathology is driven by aging and exacerbated by genetic and environmental risk factors. Peripheral blood circulation is increasingly recognised as a contributor to disease initiation and progression, and a source of biomarkers to support earlier diagnosis and personalised treatment strategies. Here we performed an analysis of plasma-derived extracellular vesicle (EV)-enriched samples from 11 AMD and 11 controls. A proteomic analysis identified significantly changed proteins in AMD, many of which appeared downregulated with a strong interaction network including AMD-associated complement proteins and endopeptidase inhibitor activity. Importantly, many of the altered proteins were previously reported AMD biomarker candidates and involved in pathways known to influence AMD: oxidative stress response, immune system functioning and proteolysis dysregulation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-06_23:39:48.278.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Carina Hansohn |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-24 22:15:51 | ID requested | |
| ⏵ 1 | 2026-09-06 23:39:48 | announced | |
Publication List
Keyword List
Contact List
| Henning Urlaub |
|---|
| contact affiliation | Max Planck Institute for Multidisciplinary Sciences, Bioanalytical Mass Spectrometry Group, Göttingen, Germany
University Medical Center Göttingen, Department of Clinical Chemistry, Bioanalytics Group, Göttingen, Germany |
| contact email | henning.urlaub@mpinat.mpg.de |
| lab head | |
| Carina Hansohn |
|---|
| contact affiliation | Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany
University Medical Center Goettingen, Göttingen, Germany |
| contact email | carina.hansohn@mpinat.mpg.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD076119 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD076119
- Label: PRIDE project
- Name: Systematic Analysis of Plasma-Derived Extracellular Vesicle-Enriched Samples in Age-Related Macular Degeneration Reveals Oxidative Stress Linked to Altered Lipid and Protein Profiles
