PXD076100 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | NEDDylation maintains oocyte quality by stabilizing mitochondrial transcription |
| Description | As women age, their oocytes decline in both quantity and quality, leading to eventual infertility. Part of this decline is associated with increased levels of reactive oxygen species and decreased mitochondrial function, which are associated with lower live birth rates. However, detailed mechanisms regulating mitochondrial function and mitochondrial decline in aged oocytes are unknown. Here we show that NEDDylation, a protein posttranslational modification, modulates mitochondrial transcription in oocytes to maintain quality over time. In this proteomic study we compared NEDDylation pathway, UBA3, knockout oocytes to control oocytes to investigate proteomic changes due to loss of NEDD8 conjugation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-06 |
| AnnouncementXML | Submission_2026-05-06_09:55:46.086.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Antrix Jain |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | ultraflex |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-24 15:26:28 | ID requested | |
| ⏵ 1 | 2026-05-06 09:55:47 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: fertility,NEDD8, oocyte, Proteomics, reproduction |
Contact List
| Stephanie A.Pangas |
|---|
| contact affiliation | Baylor College of Medicine, Houston, Texas, USA |
| contact email | spangas@bcm.edu |
| lab head | |
| Antrix Jain |
|---|
| contact affiliation | Baylor College of Medicine |
| contact email | antrixj@bcm.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD076100 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD076100
- Label: PRIDE project
- Name: NEDDylation maintains oocyte quality by stabilizing mitochondrial transcription
