PXD076099 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mouse Lymph node high endothelial venules |
| Description | High endothelial venules (HEVs) play a crucial role in adaptive immune responses in secondary lymphoid organs (SLOs). They are uniquely equipped with high levels of peripheral node addressins (PNAd), harboring carbohydrate structures that serve as L-Selectin ligands to efficiently facilitate lymphocyte homing. During inflammation, the HEV network expands in SLOs, increasing lymphocyte infiltration, but the underlying mechanisms maintaining HEVs remain underexplored. Here, we report that autophagy is essential for HEV function and expansion. Using mass spectrometry, and an inducible HEV tracer system in mice, we demonstrate that autophagy deficiency compromises LTR-signaling and the unfolded protein response in HEVs, leading to disrupted PNAd production, dedifferentiation, and reduced lymphocyte homing.Our work uncovers an unprecedented role of autophagy in safeguarding HEV identity and function during inflammation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-10 |
| AnnouncementXML | Submission_2026-07-10_04:22:22.721.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | kathryn jacobs |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | quadrupole orbitrap astral instrument |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-24 14:19:54 | ID requested | |
| ⏵ 1 | 2026-07-10 04:22:23 | announced | |
Publication List
Keyword List
| submitter keyword: inflammation, lymph node,HEVs |
Contact List
| Gabriele Bergers |
|---|
| contact affiliation | VIB center for cancer biology, KU Leuven |
| contact email | gabriele.bergers@kuleuven.be |
| lab head | |
| kathryn jacobs |
|---|
| contact affiliation | VIB center for cancer biology |
| contact email | katie7192@yahoo.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD076099 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD076099
- Label: PRIDE project
- Name: Mouse Lymph node high endothelial venules
