PXD075923-1

PXD075923 is an original dataset announced via ProteomeXchange.

Title	Chemical Proteomics Profiling with an Indole Isocyanide Photoprobe
Description	Chemoselective cysteine modification is pivotal for chemical biology and drug discovery. While photochemical strategies offer spatiotemporal control, most current methods rely on exogenous catalysts, complicating purification processes. Furthermore, the structural diversity of accessible conjugates remains limited. Here, we report an additive/catalyst-free, visible-light-driven platform for divergent cysteine modification via indole isocyanide photochemistry. This strategy eliminates the need for external additives or photocatalysts, ensuring excellent biocompatibility and operational simplicity. A key practical advantage of this method is its compatibility with both solution-phase and solid-phase reaction systems, offering unmatched flexibility for diverse experimental setups. By leveraging the tunable structure of indole isocyanides, this photoreaction readily generates a diverse array of indole-fused or indole-spiro aza-cycles at cysteine residues. We demonstrate broad utility of this method, ranging from
HostingRepository	iProX
AnnounceDate	2026-03-20
AnnouncementXML	Submission_2026-03-20_02:04:46.547.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guanghe Zhu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-20 02:04:13	ID requested
⏵ 1	2026-03-20 02:04:47	announced

Dataset with its publication pending

submitter keyword: Cysteine, Photochemistry, Indole isocyanide, Proteomics

Han Wei
contact affiliation	Zhengzhou University
contact email	fccweih2@zzu.edu.cn
lab head
Guanghe Zhu
contact affiliation	Zhengzhou University
contact email	15938824899@163.com
dataset submitter

iProX dataset URI