⮝ Full datasets listing
PXD075918-1
PXD075918 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Excitatory neurons SIRT6 mediates chronic stress‑induced depression in mice |
| Description | We used acetyl-lysine antibody-based affinity enrichment followed by mass spectrometry to identify acetylation changes caused by SIRT6 overexpression. We co-overexpressed Flag-OVOL2 and pCMV-SIRT6 in N2a cells. At 96 h after transfection, we treated cells with TSA for 12 h, collected proteins and digested proteins into peptides, enriched acetylated peptides using an anti-acetyl-lysine antibody, and then performed LC-MS/MS. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-20 |
| AnnouncementXML | Submission_2026-03-20_01:53:51.893.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Peiyi Zhou |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | acetylated residue |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-20 01:53:32 | ID requested | |
| ⏵ 1 | 2026-03-20 01:53:52 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: SIRT6, OVOL2, Deacetylation |
Contact List
| Hungchun Chang | |
|---|---|
| contact affiliation | Lingang Laboratory |
| contact email | hcchang@lglab.ac.cn |
| lab head | |
| Peiyi Zhou | |
| contact affiliation | Lingang Laboratory |
| contact email | zhoupeiyi@shanghaitech.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
