PXD075740-1

PXD075740 is an original dataset announced via ProteomeXchange.

Title	Trypanosoma cruzi modulates its histone post-translational modifications under nutritional stress
Description	Histone post-translational modifications (hPTMs) constitute one of the main regulatory mechanisms of chromatin state in eukaryotes. The presence of different hPTMs has been described in T. cruzi; however, the way these modifications are modulated during important conditions in the parasite's life cycle is still poorly understood. The nutritional stress faced by the parasite in the intestine of the invertebrate host, triggers its differentiation of non-infective into the infective form.
HostingRepository	PRIDE
AnnounceDate	2026-08-26
AnnouncementXML	Submission_2026-08-26_11:57:39.047.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rafael de Almeida
SpeciesList	scientific name: Trypanosoma cruzi Dm28c; NCBI TaxID: NEWT:1416333;
ModificationList	monomethylated residue; succinylated residue; ubiquitinylated lysine; crotonylated residue; hydroxylated residue; trimethylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; formylated residue; dimethylated residue; deamidated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-17 01:34:09	ID requested
⏵ 1	2026-08-26 11:57:39	announced

Dataset with its publication pending

submitter keyword: nutritional stress, hPTM modulation, histones, histone post-translational modifications (hPTMs),Trypanosoma cruzi

Lyris Martins Franco de Godoy
contact affiliation	Laboratório de Biologia Molecular e Sistêmica de Tripanossomatídeos, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba, Parana, Brazil
contact email	lyris.godoy@fiocruz.br
lab head
Rafael de Almeida
contact affiliation	Fiocruz
contact email	alosteria@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD075740

PRIDE project URI

• PRIDE
  1. PXD075740
     1. Label: PRIDE project
     2. Name: Trypanosoma cruzi modulates its histone post-translational modifications under nutritional stress