⮝ Full datasets listing
PXD075732-1
PXD075732 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | CHKA Promotes Glioma Growth by Suppressing Neural Development |
| Description | Objective This study aimed to investigate the role of CHKA in glioma development by integrating proteomics, bioinformatics analyses, and CHKA knockout mouse models. We assessed CHKA's impact on tumor growth, neural structural remodeling, and neural circuit homeostasis. Methods Bioinformatic analyses of CHKA downstream pathways were conducted using public databases and proteomics data. A brain glioma model with CHKA knockout mice was used. Immunohistochemistry, HE, and Luxol fast blue staining were performed to assess neuronal differentiation, synaptic structure, tumor histomorphology, and myelin integrity. Results CHKA deficiency significantly affected neural development pathways and disrupted neural circuits. In CHKA knockout glioma mice, tumor growth was suppressed, with reduced tumor area and clearer boundaries. However, neural structural abnormalities, such as impaired differentiation and synaptic dysfunction, were exacerbated. Conclusions CHKA regulates glioma progression by modulating neuronal development and synaptic function. Its deficiency inhibits tumor growth but aggravates neural structural dysfunction, highlighting its potential as a therapeutic target in gliomas. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-16 |
| AnnouncementXML | Submission_2026-03-17_00:46:32.764.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xin Qian |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-17 00:46:04 | ID requested | |
| ⏵ 1 | 2026-03-17 00:46:33 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: CHKA, glioma, nerve–tumor interaction |
| neural development |
Contact List
| Haibo Liu | |
|---|---|
| contact affiliation | Department of Neurosurgery, General Hospital of Ningxia Medical University |
| contact email | 529114289@qq.com |
| lab head | |
| Xin Qian | |
| contact affiliation | Department of Neurosurgery, General Hospital of Ningxia Medical University |
| contact email | 1154414119@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
