PXD075653-1

PXD075653 is an original dataset announced via ProteomeXchange.

Title	Neoadjuvant Camrelizumab Plus Domestically Developed Paclitaxel Polymeric Micelle and Cisplatin for Locally Advanced ESCC: a Phase Ⅱ Trial with a Plasma Proteomics Predictive Model (POINTS Trial)
Description	Plasma proteomic study for neoadjuvant therapy efficacy in locally advanced ESCC: 16 preoperative plasma samples, split into MPR/non-MPR groups (8 each) by postoperative pathology. Processed via MagReSyn® SAX magnetic bead enrichment, SDS/TCEP solubilization and trypsin digestion; analyzed by DIA-MS on Easy-nLC 1200-Orbitrap Astral (MS1:395–1005 m/z; MS2:12 m/z staggered windows). Raw data converted with ProteoWizard, library built in EncyclopeDIA, quantified in Skyline-daily. 310 DEPs identified for treatment response predictive model construction. Data collected under ethical guidelines, all patients provided written informed consent.
HostingRepository	iProX
AnnounceDate	2026-03-14
AnnouncementXML	Submission_2026-03-15_23:52:59.939.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Na Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-15 23:52:43	ID requested
⏵ 1	2026-03-15 23:53:00	announced

Dataset with its publication pending

submitter keyword: Esophageal Squamous Cell Carcinoma, Neoadjuvant Therapy, Paclitaxel Polymeric Micelle, Camrelizumab, Plasma Proteomics, Predictive Biomarker

Lei Fang
contact affiliation	Nanjing University
contact email	1783513354@qq.com
lab head
Na Li
contact affiliation	Nanjing University
contact email	502024350013@smail.nju.edu.cn
dataset submitter

iProX dataset URI