PXD075513 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Adipose Dicer-1 modulates systemic insulin signaling and longevity via a miR-8–Aop–Dilp6 axis |
| Description | This project examines how adipose tissue regulates systemic metabolism and aging in Drosophila melanogaster through the miRNA-processing enzyme Dicer-1 (Dcr-1). Proteomic profiling of fat bodies from Dcr-1 heterozygous flies was performed to identify molecular changes associated with reduced Dcr-1 activity. The dataset reveals metabolic and stress-response remodeling consistent with reduced insulin/IGF signaling, supporting a model in which decreased Dcr-1 increases Dilp6 expression in the fat body and suppresses Dilp2 secretion from brain insulin-producing cells, promoting longevity. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-13 |
| AnnouncementXML | Submission_2026-04-13_05:50:28.920.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD075513 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Andrés Dekanty |
| SpeciesList | scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: NEWT:7227; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-11 14:12:57 | ID requested | |
| ⏵ 1 | 2026-04-13 05:50:29 | announced | |
Publication List
Keyword List
| submitter keyword: insulin like peptides,miRNA, adipose tissue, oxidative stress,inter organ communication |
Contact List
| Andres Dekanty |
|---|
| contact affiliation | Laboratorio de Biología Molecular - Instituto de Agrobiotecnología del Litoral - CONICET - Santa Fe,Argentina |
| contact email | adekanty@ial.unl.edu.ar |
| lab head | |
| Andrés Dekanty |
|---|
| contact affiliation | CONICET |
| contact email | adekanty@ial.unl.edu.ar |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD075513 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD075513
- Label: PRIDE project
- Name: Adipose Dicer-1 modulates systemic insulin signaling and longevity via a miR-8–Aop–Dilp6 axis
