PXD075354 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic identification of primate-specific lncRNA LINC01021 interactors via RNA pull-down MS |
| Description | Long non-coding RNAs (lncRNAs) play critical regulatory roles in primate-specific biological processes, yet many primate-specific lncRNAs and their protein interactors remain poorly characterized. In this study, we focused on primate-specific lncRNAs as potential drivers of protein interactions. Using RNA affinity pull-down coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS), we identified proteins interacting with LINC01021 in primate-derived cells. Key findings include specific enrichment of RBMS proteins, suggesting a functional role in RNA metabolism or gene regulation. This dataset provides proteomic evidence for primate-specific lncRNA-protein interactions and contributes to understanding evolutionary adaptations in primates. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-29 |
| AnnouncementXML | Submission_2026-06-28_16:26:29.239.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yan Zhang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-07 11:21:19 | ID requested | |
| ⏵ 1 | 2026-06-28 16:26:30 | announced | |
Publication List
| 10.1111/acel.70603; |
| Zhang Y, Hu L, Dong X, Zeng Q, Zi M, Nisar A, Khan S, Bai R, Liu C, Ge M, Pu S, Li G, He Y, A Primate-Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1-Dependent Destabilization of RBMX. Aging Cell, 25(7):e70603(2026) [pubmed] |
Keyword List
| submitter keyword: long non-coding RNA, proteomics,lncRNA, mass spectrometry, protein-RNA interaction, LINC01021, primate-specific lncRNA, RNA-binding protein, interactome, RBMS, RNA pull-down |
Contact List
| Yonghan He |
|---|
| contact affiliation | 1. State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China 2. University of Chinese Academy of Sciences, Beijing 100101, China 3. KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming 650201, China |
| contact email | heyonghan@mail.kiz.ac.cn |
| lab head | |
| Yan Zhang |
|---|
| contact affiliation | State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China |
| contact email | zhangyan1@mail.kiz.ac.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD075354
- Label: PRIDE project
- Name: Proteomic identification of primate-specific lncRNA LINC01021 interactors via RNA pull-down MS
