PXD075285-1

PXD075285 is an original dataset announced via ProteomeXchange.

Title	Proteomic profile of urinary extracellular vesicles from rats with lithium-induced nephrogenic diabetes insipidus
Description	Bipolar disorder is a chronic psychiatric disorder characterized by recurrent episodes of mania and depression affecting more than 0.5% of the world’s population. Lithium (Li) is the gold-standard treatment for bipolar disorder and treatment-resistant unipolar depression due to its potent effects on preventing both manic and depressive episode. Patients who are taking Li for more than 10-20 years are at risk of chronic kidney disease, which ultimately can lead to end-stage renal disease, hemodialysis, kidney transplantation, and mortality. The Li-induced nephropathy includes interstitial fibrosis, microcysts originating from the distal tubule and the collecting duct, glomerulosclerosis, and tubular atrophy of the proximal tubule as evidenced in human renal biopsies and animal studies. Therefore, the purpose of the present study was to examine using mass spectrometry whether the effects of Li treatment for 2 or 4-weeks on rat kidney proteins are reflected in urinary extracellular vesicles (uEVs).
HostingRepository	PRIDE
AnnounceDate	2026-06-30
AnnouncementXML	Submission_2026-06-30_03:44:41.689.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qi Wu
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-05 13:50:00	ID requested
⏵ 1	2026-06-30 03:44:42	announced

Dataset with its publication pending

submitter keyword: Histone H4, mass spectrometry, Keratin 8, biomarkers

Qi Wu
contact affiliation	Department of Biomedicine, Aarhus University
contact email	qi.wu@biomed.au.dk
lab head
Qi Wu
contact affiliation	Department of Biomedicine, Aarhus University
contact email	qi.wu@biomed.au.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD075285

PRIDE project URI

• PRIDE
  1. PXD075285
     1. Label: PRIDE project
     2. Name: Proteomic profile of urinary extracellular vesicles from rats with lithium-induced nephrogenic diabetes insipidus