PXD075156 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of extracellular membrane vesicles produced from Staphylococcus aureus biofilm and planktonic cultures |
| Description | This project investigates the role of extracellular membrane vesicles (MVs) in Staphylococcus aureus biofilm formation. To elucidate how MVs contribute to this process, we conducted a proteomic analysis to identify and compare proteins present in the S. aureus MN8 biofilm matrix, as well as proteins associated with MVs purified from MN8 biofilm and planktonic cultures. We identified 747 proteins in the biofilm matrix and 730 proteins in MVs purified from the biofilm, of which 576 were shared. Abundance-based correlation analysis revealed a strong positive correlation between these two protein sets. In contrast, only 568 proteins were detected in MVs derived from MN8 planktonic cultures, which exhibited a distinct composition, particularly in the cytoplasmic protein category, compared to biofilm-associated MVs. Overall, our findings demonstrate that the protein cargo of biofilm-derived MVs closely mirrors the biofilm matrix proteome, suggesting that MVs play a significant role in biofilm formation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-03 |
| AnnouncementXML | Submission_2026-08-03_06:18:18.809.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jinger Lei |
| SpeciesList | scientific name: Staphylococcus aureus subsp. aureus MN8; NCBI TaxID: NEWT:548470; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-03-03 11:35:25 | ID requested | |
| ⏵ 1 | 2026-08-03 06:18:19 | announced | |
Publication List
Keyword List
| submitter keyword: extracellular vesicles, MN8, biofilm,Staphylococcus aureus, biofilm matrix |
Contact List
| Xiaogang Wang |
|---|
| contact affiliation | Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States. |
| contact email | xgwang@vt.edu |
| lab head | |
| Jinger Lei |
|---|
| contact affiliation | Department of Biomedical Sciences and Pathobiology
Virginia-Maryland College of Veterinary Medicine, Virginia Tech |
| contact email | jingerlei@vt.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD075156 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD075156
- Label: PRIDE project
- Name: Proteomic analysis of extracellular membrane vesicles produced from Staphylococcus aureus biofilm and planktonic cultures
