⮝ Full datasets listing
PXD075116-2
PXD075116 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation |
| Description | CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-03 |
| AnnouncementXML | Submission_2026-05-19_00:06:30.453.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Leixi Cao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue |
| Instrument | Q Exactive HF-X; timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-02 17:40:14 | ID requested | |
| 1 | 2026-03-03 01:21:22 | announced | |
| ⏵ 2 | 2026-05-19 00:06:31 | announced | 2026-05-19: Add info |
Publication List
| Wang R, Cao L, He X, Thorne RF, Wu Q, Ding C, Zhang J, Li M, Shi Z, Dong X, Li J, Li H, Gao S, Li J, Zhang XD, Jin L, Fan T, Wu M, A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation. Proc Natl Acad Sci U S A, 123(12):e2523253123(2026) [pubmed] |
Keyword List
| submitter keyword: CHKA, PML, WIPI2 |
Contact List
| Mian Wu | |
|---|---|
| contact affiliation | Zhengzhou University, Zhengzhou University People's Hospital, Translational Medicine Research Center |
| contact email | wumian@ustc.edu.cn |
| lab head | |
| Leixi Cao | |
| contact affiliation | Zhengzhou University, Zhengzhou University People's Hospital, Translational Medicine Research Center |
| contact email | 1585529834@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
