⮝ Full datasets listing
PXD075088-1
PXD075088 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Plasma Proteomics Reveals Persistent and Surgery-Responsive Molecular Signatures in Osteoarthritis Patients |
| Description | Osteoarthritis (OA) is a progressive degenerative joint disorder characterized by cartilage degradation, synovial inflammation, and alterations in subchondral bone, ultimately leading to chronic pain and impaired mobility. This study aimed to identify plasma proteomic alterations in OA patients before and after arthroplasty in order to reveal biomarkers associated with both ongoing disease processes and postoperative recovery. The study cohort consisted of eighteen individuals: eight OA patients undergoing total knee or hip arthroplasty and ten healthy controls matched for age, sex, and body mass index. Plasma samples were depleted of high-abundance proteins, enzymatically digested, and subsequently analyzed using liquid chromatography–tandem mass spectrometry (LC–MS/MS) to characterize proteomic changes. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-03-30 |
| AnnouncementXML | Submission_2026-03-29_08:00:04.733.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hayriye Ecem Yelkenci |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | Synapt MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-02 08:28:34 | ID requested | |
| ⏵ 1 | 2026-03-29 08:00:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: osteoarthritis, proteomics |
Contact List
| Duygu Sari Ak, Mustafa Caglar Beker | |
|---|---|
| lab head | |
| Hayriye Ecem Yelkenci | |
| contact affiliation | Istanbul Medipol University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004442/ |
