PXD074977-1

PXD074977 is an original dataset announced via ProteomeXchange.

Title	Serum proteomic analysis of U-NK cell-mediated enhancement of hematopoietic engraftment post-allo-HSST using LC-MS/MS
Description	To elucidate the mechanisms by which donor-derived unlicensed natural killer (U-NK) cells promote hematopoietic engraftment, we performed a comparative serum proteomic analysis. Using liquid chromatography–tandem mass spectrometry (LC-MS/MS), we profiled serum proteins from recipient mice on day 21 post-transplantation. Three groups were compared: mice infused with U-NK cells, those infused with licensed NK (L-NK) cells, and a control group receiving bone marrow reinfusion only. This time point was selected as it marks the first significant divergence in hematopoietic reconstitution between groups. The analysis aims to identify differentially expressed proteins and pathways associated with the enhanced neutrophil and platelet recovery observed in U-NK cell recipients, with a focus on proteins related to hematopoietic stem cell homing and stromal interaction.
HostingRepository	iProX
AnnounceDate	2026-02-27
AnnouncementXML	Submission_2026-07-01_01:06:36.429.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ming Zhao
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Bruker Daltonics amaZon series

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-27 00:29:33	ID requested
⏵ 1	2026-07-01 01:06:36	announced

Dataset with its publication pending

submitter keyword: Hematopoietic stem cell transplantation, Unlicensed NK cells, Hematopoietic engraftment, Proteomics, LC-MS/MS, Mouse model

Xiangyu Zhao
contact affiliation	Peking University People’s Hospital
contact email	Zhao_xy@bjmu.edu.cn
lab head
Ming Zhao
contact affiliation	Capital Medical University
contact email	1369151452@qq.com
dataset submitter

iProX dataset URI