PXD074827-2

PXD074827 is an original dataset announced via ProteomeXchange.

Title	PFKM promotes the survival of GBM cells under glucose deprivation
Description	PFKM is the second rate-limiting step of glycolysis, catalyzing the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate. Here we show, using an orthotopic xenograft glioma mouse model, that PFKM is deubiquitinated and translocated into nucleus upon glucose deficiency, thereby activating fatty acid oxidation (FAO), which sustains tumor cell survival and ultimately promotes GBM development.
HostingRepository	iProX
AnnounceDate	2026-02-15
AnnouncementXML	Submission_2026-05-21_00:43:17.044.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Siyang Wu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-24 18:25:52	ID requested
1	2026-05-06 18:27:10	announced
⏵ 2	2026-05-21 00:43:18	announced	2026-05-21: Add info

Wu S, Cao R, Huang X, Feng Q, Zhang Y, Gao H, Tao B, Liang J, Yang W, USP7 facilitates brain tumor survival upon glucose deprivation by regulating phosphofructokinase muscle-type nuclear translocation in mice. PLoS Biol, 24(3):e3003698(2026) [pubmed]

submitter keyword: PFKM, Cancer Metabolism

Weiwei Yang
contact affiliation	Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
contact email	wyang@sibcb.ac.cn
lab head
Siyang Wu
contact affiliation	Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
contact email	wusiyang0815@163.com
dataset submitter

iProX dataset URI