PXD074772-1

PXD074772 is an original dataset announced via ProteomeXchange.

Title	Myeloid cell recruitment propels right ventricular dysfunction in HFpEF via sterile inflammation
Description	This project characterizes chamber-specific proteomic remodeling in a murine three-hit HFpEF model that develops right ventricular dysfunction, using chow, hypoxia alone, and HFD+L-NAME as control conditions. The three-hit model (hypoxia, high-fat diet, and L-NAME) recapitulates key features of human HFpEF, including left ventricular diastolic dysfunction and secondary right ventricular hypertrophy and dysfunction.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-07_04:20:37.682.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pauline Fahjen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-24 10:00:39	ID requested
⏵ 1	2026-09-07 04:20:38	announced

10.1161/circulationaha.125.078476;

Jaeschke L, Ko, ç, ana C, Chitroceanu AM, Winkler A, Kleitke H, Fahjen P, Kamp J, Faidel D, Asmus E, Meiser M, Stamatiades EG, Hublitz KW, Zach V, Kretzler L, Zurkan D, Perret PL, von der Ohe LA, Beckschulte K, Simmons S, Gillan JL, Franz K, Alasfar L, Hahn VS, Sharma K, Reynolds E, Schiattarella GG, van Linthout S, Pieske B, Beyhoff N, Ott C, Hegemann N, Mertins P, Edelmann F, Kuebler WM, Grune J, Myeloid Cell Expansion Propels Right Ventricular Dysfunction in HFpEF Through Sterile Inflammation. Circulation, ():(2026) [pubmed]

submitter keyword: Heart, Mouse,HFpEF, Hypoxia

Philipp Mertins
contact affiliation	Max Delbrueck Center, Berlin, Germany Berlin Institute of Health, Berlin, Germany
contact email	philipp.mertins@mdc-berlin.de
lab head
Pauline Fahjen
contact affiliation	Max-Delbrueck-Center for Molecular Medicine
contact email	pauline.fahjen@mdc-berlin.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD074772

PRIDE project URI

• PRIDE
  1. PXD074772
     1. Label: PRIDE project
     2. Name: Myeloid cell recruitment propels right ventricular dysfunction in HFpEF via sterile inflammation