PXD074668 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nitrate-responsive Sialin2 Couples Stress Granule Assembly and Clearance to Maintain Neuronal Homeostasis |
| Description | Stress granules (SGs) are phase-separated ribonucleoprotein condensates that support cellular adaptation to acute stress, but how extracellular signals coordinate their assembly and recovery-phase clearance remains unclear. Here, we show that nitrate-responsive Sialin2 coordinates SG homeostasis across the stress cycle. During acute stress, Sialin2 undergoes liquid-liquid phase separation and co-assembles with G3BP-centered scaffolds to promote SG formation. During recovery, Sialin2 preserves liquid-like SG dynamics and promotes autophagy-linked clearance. Sialin2 loss delays SG resolution, promotes retention of ALS-linked FUS and TDP-43 variants, and enhances APP-related amyloidogenic output. In an ALS mouse model, nitrate treatment reduces SG-like pathology and neuroinflammation, preserves neuronal integrity, and delays functional decline. Together, these findings define a nitrate-Sialin2 signaling module that couples SG assembly to recovery-phase clearance and links inorganic anion sensing to protection against neurodegeneration. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-03 |
| AnnouncementXML | Submission_2026-09-03_09:07:55.995.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xiaoyu Li |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-19 21:35:06 | ID requested | |
| ⏵ 1 | 2026-09-03 09:07:56 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Nitrate |
| Sialin2 |
| Stress granules |
| Liquid-liquid phase separation |
| Autophagy |
| Neurodegeneration |
Contact List
| Xiaoyu Li |
|---|
| contact affiliation | Beijing, You An Men Wai Xi Tou Tiao No.10, Capital Medical University, Beijing Laboratory of Oral Health |
| contact email | xiaoyu9449@ccmu.edu.cn |
| lab head | |
| Xiaoyu Li |
|---|
| contact affiliation | Capital Medical University |
| contact email | xiaoyu9449@ccmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD074668 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074668
- Label: PRIDE project
- Name: Nitrate-responsive Sialin2 Couples Stress Granule Assembly and Clearance to Maintain Neuronal Homeostasis
