PXD074613-1

PXD074613 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteo-metabolomic analysis of plasma exosomes identifies novel biomarkers of thrombo-inflammation and disease progression in pediatric neuroblastoma
Description	Neuroblastoma (NB) is a heterogeneous pediatric solid tumor in which minimally invasive biomarkers that reflect tumor biology and treatment response remain limited. Plasma exosomes contain proteins and metabolites that may provide insight into neuroblastoma pathophysiology and enable the identification of mechanistically linked biomarkers. This study employed an integrated proteo-metabolomic approach to identify novel exosomal biomarkers associated with disease status. Plasma samples were obtained from 14 patients with neuroblastoma before tumor resection (on-disease), 15 patients after tumor resection (follow-up), and 20 healthy donors. Plasma exosomes were characterized by transmission electron microscopy, nanoparticle tracking analysis, and immunoblotting. SWATH-targeted proteomic profiling identified 16 significantly altered exosomal proteins, and bioinformatic analysis revealed platelet activation, coagulation cascades, and growth-related signaling, all centralized on exosomal alpha-2-macroglobulin (A2M), which showed the highest level in the on-disease group and declined in the follow-up and healthy control groups.
HostingRepository	jPOST
AnnounceDate	2026-02-19
AnnouncementXML	Submission_2026-02-18_17:47:40.469.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dr.Wararat Chiangjong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-18 17:47:37	ID requested
⏵ 1	2026-02-18 17:47:40	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: neuroblastoma
biomarkers
proteomics
metabolomics
extracellular vesicle

submitter keyword: neuroblastoma

biomarkers

proteomics

metabolomics

extracellular vesicle

Contact List

Wararat Chiangjong
lab head
Dr.Wararat Chiangjong
contact affiliation	Mahidol University
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004423/