PXD074506-1

PXD074506 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of obesity-associated metabolic and immune changes in Göttingen minipigs
Description	Obesity is a well-established risk factor for increased severity following influenza A virus (IAV) infection, likely through meta-inflammation and immune dysregulation. The mechanisms by which obesity alters antiviral and inflammatory responses remain poorly understood. Using a diet-induced obesity model in Göttingen minipigs, we compared immune and inflammatory responses between obese and lean animals before and after IAV infection. While uninfected pigs showed no clear obesity-associated immune or histological changes in the respiratory tract, obese pigs exhibited reduced viral clearance, altered antiviral gene expression, and increased cellular infiltration post-infection, alongside elevated C-reactive protein levels. This indicates that innate antiviral immunity is affected post-infection in obese animals, potentially contributing to more severe influenza outcomes. The proteomics dataset included here, however, reflects only the obese versus lean state prior to infection, providing insights into baseline metabolic and inflammatory differences. This model demonstrates high translational value for studying obesity-associated immune modulation.
HostingRepository	PRIDE
AnnounceDate	2026-07-15
AnnouncementXML	Submission_2026-07-14_23:56:18.889.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Betina Lyngfeldt Henriksen
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: NEWT:9825;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-16 03:46:33	ID requested
⏵ 1	2026-07-14 23:56:19	announced

Dataset with its publication pending

submitter keyword: Orbitrap Exploris, Lung, Obesity,Pig

Kerstin Skovgaard
contact affiliation	Antiviral Immunomics, Bioengineering, Technical University of Denmark, Denmark
contact email	kesk@dtu.dk
lab head
Betina Lyngfeldt Henriksen
contact affiliation	Technical University of Denmark
contact email	blyhen@dtu.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD074506

PRIDE project URI

• PRIDE
  1. PXD074506
     1. Label: PRIDE project
     2. Name: Proteomic profiling of obesity-associated metabolic and immune changes in Göttingen minipigs