PXD074495 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantification of glycated rat serum albumin peptides |
| Description | Serum albumin is the most abundant plasma protein with a large number of lysine and arginine residues. Hence, it is highly susceptible to glycation, a non-enzymatic reaction involving binding of non-reducing sugars to proteins, in vivo. Oxidative stress is known to promote glycation and the Advanced glycation end products (AGEs) formed through glycation bind to their cell-surface receptor (RAGE). AGE-RAGE interaction activates downstream intracellular signaling pathways resulting in increased inflammation and oxidative stress and the vicious cycle of Oxidative stress and AGE formation continues. Here we quantified glycated albumin peptides mass spectrometrically in maternally separated rats and compared their levels with those in Control to investigte if AGE accumulation is associated with the increased inflammation and oxidative stress in MS rats. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-29 |
| AnnouncementXML | Submission_2026-06-28_16:25:38.639.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Arvindkumar Chaurasiya |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116; |
| ModificationList | N6-1-carboxyethyl-L-lysine; methylglyoxal arginine adduct (+54 amu); iodoacetic acid derivatized residue |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-15 13:57:07 | ID requested | |
| ⏵ 1 | 2026-06-28 16:25:39 | announced | |
Publication List
| 10.3389/fncel.2026.1809602; |
| Chaudhari PR, Chaurasiya AH, Vaidya ADB, Kulkarni MJ, Vaidya VA, A history of maternal separation drives systemic aging-associated signatures in middle-aged male rats. Front Cell Neurosci, 20():1809602(2026) [pubmed] |
Keyword List
| submitter keyword: glycation, SWATH-mass spectrometry, serum, albumin peptides,Middle-aged rats |
Contact List
| Mahesh J Kulkarni |
|---|
| contact affiliation | Proteomics facility, Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, India |
| contact email | mj.kulkarni@ncl.res.in |
| lab head | |
| Arvindkumar Chaurasiya |
|---|
| contact affiliation | CSIR-National Chemical Laboratory |
| contact email | akhc1986@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074495
- Label: PRIDE project
- Name: Quantification of glycated rat serum albumin peptides
