PXD074461 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of the anticancer effect of an antimicrobial myristoylated peptide |
| Description | Antimicrobial peptides (AMPs),bioactive against multidrug-resistant (MDR) human pathogens, are promising candidates to counteract the antimicrobial resistance. Strong efforts are in progress to bring AMPs into clinical use and they are also being investigated as anticancer agents. In this context, we identified an Antarctic fish-derived AMP, named chionodracine. Based on its scaffold, we designed a chionodracine mutant peptide and three shorter N-myristoylated (myr) peptides active against some MDR pathogens To deeply investigate the molecular effects of Myr-B in HeLa cells, we employed label-free shotgun quantitative proteomics coupled with bioinformatics comparing three experimental groups: untreated, Pep-B- and Myr-B-treated cells. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-06 |
| AnnouncementXML | Submission_2026-05-06_03:00:42.814.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Michele Costanzo |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-13 14:57:49 | ID requested | |
| ⏵ 1 | 2026-05-06 03:00:43 | announced | |
Publication List
Keyword List
| submitter keyword: proteomics, cancer therapies, myristoilated peptides, cancer cells, antimicrobial peptides |
Contact List
| Michele Costanzo |
|---|
| contact affiliation | Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II |
| contact email | michele.costanzo@unina.it |
| lab head | |
| Michele Costanzo |
|---|
| contact affiliation | Department of Molecular Medicine and Medical Biotechnology - University of Naples Federico II |
| contact email | michele.costanzo@unina.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD074461 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074461
- Label: PRIDE project
- Name: Proteomic analysis of the anticancer effect of an antimicrobial myristoylated peptide
