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PXD074295-1

PXD074295 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAdaptability and Functional Compensation of the Immune Regulatory Network in Haemaphysalis longicornis
DescriptionClimate warming not only enhances the activity of ticks but may also promote the activation and proliferation of pathogens within them, thereby increasing the risk of tick-borne disease transmission. Defensins, as key effector molecules of tick innate immunity, effectively regulate the levels of pathogens in the host; however, the cooperative mechanisms between defensins and other immune molecules remain unclear. This study investigated the impact of elevated temperature on the proliferation of Rickettsia within the hard tick Haemaphysalis longicornis. By employing RNA interference to silence specific defensin genes and combining quantitative proteomic analysis, we found that following defensin knockdown, the load of Rickettsia in ticks increased to some extent, while the expression of several immune-related proteins, including Hemolectin and serine protease inhibitors, was significantly upregulated. These results suggest that ticks may activate a compensatory immune regulatory network to cope with the loss of key defense molecules. This study systematically reveals the elastic regulatory mechanisms of the tick immune network under infection pressure and provides a new perspective for a deeper understanding of the “host–pathogen–environment” interaction.
HostingRepositoryiProX
AnnounceDate2026-02-10
AnnouncementXMLSubmission_2026-02-10_01:27:24.266.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNingmei Wang
SpeciesList scientific name: Haemaphysalis longicornis; NCBI TaxID: 44386;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02026-02-10 01:26:49ID requested
12026-02-10 01:27:24announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Haemaphysalis longicornis, defensin, RNA interference, proteomics
Contact List
Hui Wang
contact affiliationHebei Normal University
contact emailwhui1981@163.com
lab head
Ningmei Wang
contact affiliationHebei Normal University
contact email767247571@qq.com
dataset submitter
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