⮝ Full datasets listing
PXD074284-1
PXD074284 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Single-oocyte proteome-transcriptome co-profiling for oocyte aging |
| Description | We performed single-cell proteome/transcriptome co-profiling in GV and MII-aged oocytes from mice and humans, revealing species- and stage-specific proteomic/transcriptomic changes during oocyte aging. Strikingly, we observed uncoupled proteomic and transcriptomic alterations, indicating that proteomic changes in aged oocytes are not primarily driven by RNA alterations. Leveraging our single-cell profiling, we identified molecular features underlying quality heterogeneity in aged oocytes and revealed MCT4 as a conserved oocyte aging biomarker. |
| HostingRepository | iProX |
| AnnounceDate | 2026-02-10 |
| AnnouncementXML | Submission_2026-09-06_19:57:50.736.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yirong Jiang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-09 19:50:20 | ID requested | |
| ⏵ 1 | 2026-09-06 19:57:51 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Single-oocyte proteome-transcriptome co-profiling, mouse and human oocyte aging |
Contact List
| Xudong Fu | |
|---|---|
| contact affiliation | Zhejiang University |
| contact email | xudongfu@zju.edu.cn |
| lab head | |
| Yirong Jiang | |
| contact affiliation | Zhejiang University |
| contact email | yrjiang@zju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
