⮝ Full datasets listing
PXD074283-1
PXD074283 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative Proteomics of mPFC Tissue in a Vascular Cognitive Impairment Mouse Model |
| Description | Deep quantitative proteomic profiling of bilateral medial prefrontal cortex (mPFC) from control (ctrl), vascular cognitive impairment (VCI, model) and EVs treatment (test) mice (3 biological replicates each). Proteins extracted with RIPA + inhibitors, quantified by BCA, processed via FASP, digested with trypsin, labeled with TMT-16plex, fractionated by high-pH RP, and analyzed on nanoLC-Q Exactive HF-X (DDA, 120k/15k resolution). Raw files searched against Mus musculus UniProt in PD 3.0/Mascot (FDR ≤1%). Differentiation criteria: fold-change >1.2, p<0.05 (Perseus). |
| HostingRepository | iProX |
| AnnounceDate | 2026-02-10 |
| AnnouncementXML | Submission_2026-02-09_19:48:53.653.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yue Hei |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-09 19:48:37 | ID requested | |
| ⏵ 1 | 2026-02-09 19:48:54 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: mPFC, VCI, mouse, quantitative proteomics, EVs treatment, differential expression |
Contact List
| Yue Hei | |
|---|---|
| contact affiliation | Fourth Military Medical University |
| contact email | heiyue@fmmu.edu.cn |
| lab head | |
| Yue Hei | |
| contact affiliation | Fourth Military Medical University |
| contact email | heiyue1990@yeah.net |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
