PXD074276 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | CBG and EAA for melanocytes protection |
| Description | Aims: This study aims to assess the effect of simultaneous use of cannabigerol (CBG) and 3-O-ethyl ascorbic acid (EAA) on changes in the skin melanocyte proteome induced by UVA radiation, with particular emphasis on modifications in the structure of metabolically important proteins. Results: Proteomic analysis allowed to identify 1248 proteins with statistically significantly changed expression following melanocytes irradiation and/or incubation with CBG/EAA. The top 25 proteins with most strongly modified expression included mainly proteins involved in cells protection/antioxidant response, as well as pro-inflammatory and proapoptotic signalization. Moreover, in melanocytes irradiated with UVA, the levels of lipid peroxidation product, 4-hydroxynonenal (4-HNE) and its protein adducts increase, as well as significant changes in the profile of proteins modified by 4-HNE are observed. CBG and EAA, especially when used together, largely reverse this effect. Innovation: This study for the first time shows the combined effect of CBG and EAA on the proteome of melanocytes after their exposure to UVA radiation, that applies to both changes in protein expression and intracellular signaling based on protein modification by lipid peroxidation products. Conclusion: It can be summarized that CBG and EAA can provide melanocytes with the most effective protection against oxidative stress, and perhaps even protect the skin structure against carcinogenesis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-15 |
| AnnouncementXML | Submission_2026-06-14_16:10:38.431.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Agnieszka Gęgotek |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-09 19:36:48 | ID requested | |
| ⏵ 1 | 2026-06-14 16:10:39 | announced | |
Publication List
| Mucha M, Ry, š, av, á A, Jarocka-Karpowicz I, Maru, š, ka A, Skrzydlewska E, G, ę, gotek A, -Ethylascorbic Acid. Cells, 15(11):(2026) [pubmed] |
| 10.3390/cells15110965; |
Keyword List
| submitter keyword: melanocytes |
| UVA radiation |
| cannabigerol |
| 3-O-ethyl ascorbic acid |
| proteomics |
| skin protection; |
Contact List
| Agnieszka Gęgotek |
|---|
| contact affiliation | UMB |
| contact email | agnieszkagegotek@o2.pl |
| lab head | |
| Agnieszka Gęgotek |
|---|
| contact affiliation | Medical University of Białystok |
| contact email | agnieszkagegotek@o2.pl |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD074276 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074276
- Label: PRIDE project
- Name: CBG and EAA for melanocytes protection
