PXD074203 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Analysis of Canine Extracellular Matrix in Mammary Tumor Progression |
| Description | Canine mammary gland tumors are common and bear striking similarities to human breast cancer, making them a valuable model for comparative oncology. This study examined changes in the extracellular matrix (ECM) associated with tumor progression in spontaneous canine mammary carcinomas, aiming to identify biomarkers linked to tumor aggressiveness. Normal, non-metastatic, and metastatic mammary tissues were analyzed by histological and proteomic approaches, and human breast cancer transcriptomic data were explored for in silico validation. Histological analysis with special stains revealed a reduction in type III collagen in metastatic tumors. The proteomic profile identified 12 MEC-related proteins with differential expressions in canine samples, of which eight were upregulated (COL12A1, COL4A1, COL4A2, SERPINH1, SERPINF1, HTRA1, TNC, PCOLCE) and four (MMRN1, ABI3BP, DPT, OGN) were downregulated and were confirmed to be differentially expressed in the human transcriptome as well. The results highlight the active remodeling of the ECM during tumor progression, marked by increased expression of proteins associated with stiffness and invasiveness and decreased expression of potential suppressors. These findings strengthen the understanding of ECM dynamics in breast cancer and suggest promising molecular targets for future investigations. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-13 |
| AnnouncementXML | Submission_2026-04-12_16:10:47.555.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Michel Batista |
| SpeciesList | scientific name: Canis familiaris (Dog) (Canis lupus familiaris); NCBI TaxID: NEWT:9615; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-08 18:19:12 | ID requested | |
| ⏵ 1 | 2026-04-12 16:10:48 | announced | |
Publication List
| de Almeida BS, Rocha GV, Nunes S, Zanette DL, Batista M, Estrela-Lima A, Regis-Silva CG, Damasceno KA, Comparative omics reveals conserved extracellular matrix signatures during mammary tumor progression. Front Oncol, 16():1788746(2026) [pubmed] |
| 10.3389/fonc.2026.1788746; |
Keyword List
| submitter keyword: proteomics,Canine mammary tumor, extracellular matrix, LC-MS/MS |
Contact List
| Karine Araújo Damasceno |
|---|
| contact affiliation | Laboratory for Global Health Research and Neglected Diseases, Gonçalo Moniz Institute, Oswaldo Cruz Foundation, BA, Brazil |
| contact email | karine.damasceno@fiocruz.br |
| lab head | |
| Michel Batista |
|---|
| contact affiliation | Fiocruz |
| contact email | batista.mic@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074203
- Label: PRIDE project
- Name: Proteomic Analysis of Canine Extracellular Matrix in Mammary Tumor Progression
