PXD074114-1

PXD074114 is an original dataset announced via ProteomeXchange.

Title	Proteomic identification of candidate biomarkers associated with acquired tolerance to ionizing radiation
Description	Radiation resistance is a significant issue, leading to the failure of radiation therapy and tumor relapse. This study aims to select an X-ray-resistant S. cerevisiae strain to evaluate deregulated proteins in response to high ionizing radiation exposure, with the goal of identifying candidate molecular biomarkers. A wild-type (wt) strain was exposed to increasing doses of X-rays until a resistant strain was obtained. Survival was assessed, and proteomic analysis was performed via mass spectrometry. The resistant cells exhibited 9.38 times greater resistance than the wt strain. Several deregulated proteins were identified. These findings indicate that acquired radiation resistance at high doses is associated with the increased expression of GAPDH and ENO1, which are proposed as candidate molecular biomarkers associated with acquired radiation tolerance, pending further functional validation. Data are available via ProteomeXchange with identifier PXD074114.
HostingRepository	PRIDE
AnnounceDate	2026-08-14
AnnouncementXML	Submission_2026-08-14_01:52:29.481.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Miguel Ruiz-Gomez
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: NEWT:4932;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-05 19:03:41	ID requested
⏵ 1	2026-08-14 01:52:29	announced

10.1016/J.RADPHYSCHEM.2026.114370;

10.1016/j.radphyschem.2026.114370;

submitter keyword: Resistance, TDH2, ENO1, GAPDH, X-ray, Proteomics, Biomarker

Miguel José Ruiz-Gómez
contact affiliation	Department of Radiology and Physical Medicine, Faculty of Medicine, University of Málaga, Málaga, Spain
contact email	mjrg@uma.es
lab head
Miguel Ruiz-Gomez
contact affiliation	University of Malaga
contact email	mjrg@uma.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD074114

PRIDE project URI

• PRIDE
  1. PXD074114
     1. Label: PRIDE project
     2. Name: Proteomic identification of candidate biomarkers associated with acquired tolerance to ionizing radiation