PXD074113-1

PXD074113 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Assessing extracellular vesicle proteins as predictive biomarkers for developing type 1 diabetes
Description	Proteomic data from human plasma from donors; grouped into islet autoimmunity (n=19) and control (n=17) individuals. Plasma extracellular vesicles were enriched using strong anion exchange (SAX) beads from Resyn Biosciences, and workflow automated on a KingFisher Flex platform. Samples were reduced, alkylated, and digested with trypsin (1:20 (w/w) enzyme-to-protein ratio). Samples were analyzed on the Orbitrap Astral MS. Data was searched with DIA-NN using PNNL's DMS processing pipeline.
HostingRepository	MassIVE
AnnounceDate	2026-05-19
AnnouncementXML	Submission_2026-05-19_12:06:06.882.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matthew Monroe
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl; Acetyl
Instrument	Orbitrap Astral

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-05 18:13:45	ID requested
⏵ 1	2026-05-19 12:06:07	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: extracellular vesicles, plasma, DatasetType:Proteomics

submitter keyword: extracellular vesicles, plasma, DatasetType:Proteomics

Contact List

Ernesto S. Nakayasu
contact affiliation	Pacific Northwest National Laboratory
contact email	ernesto.nakayasu@pnnl.gov
lab head
Matthew Monroe
contact affiliation	Pacific Northwest National Laboratory
contact email	matthew.monroe@pnnl.gov
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v12/MSV000100738/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v12/MSV000100738/