⮝ Full datasets listing
PXD074112-1
PXD074112 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Epigenetic and transcriptomic impacts of ethanol vary by brain region and extent of exposure |
| Description | Epigenetic and transcriptional mechanisms are key contributors to alcohol use disorder (AUD). However, a better understanding of the specific genes, transcripts, and chromatin marks affected is necessary to inform novel pharmacotherapies. Here, we systematically investigate the genome-wide epigenetic and transcriptomic effects of ethanol across key brain regions relevant to AUD and assess how these outcomes differ between acute and chronic exposure in male C57BL/6J mice. We show that alcohol-derived acetate contributes to histone acetylation in the brain in response to acute or chronic exposure, with a broader and more robust effect following repeated exposure. Further, we find that chromatin and transcriptomic changes elicited by acute or chronic ethanol exposure are predominantly specific to brain region, and observe more robust dysregulation of gene and transcript expression following acute exposure. We show that ethanol-induced transcriptional changes are paradigm-dependent in some brain regions, most strikingly in the ventral hippocampus. Overall, our results systematically illuminate and compare key epigenetic and transcriptomic outcomes linked to acute and chronic ethanol exposure, which will guide the development of future therapeutic interventions. The raw mass spectrometry data for this study are deposited here. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-03-30 |
| AnnouncementXML | Submission_2026-03-30_10:04:03.573.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Gabor Egervari |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Acetyl; Methyl; Dimethyl; Trimethyl |
| Instrument | Orbitrap Ascend; Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-05 16:13:51 | ID requested | |
| ⏵ 1 | 2026-03-30 10:04:04 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: brain, ethanol, alcohol, translational research, cortex, hippocampus, striatum, stable isotope labeling, DatasetType:Proteomics, mouse |
Contact List
| Gabor Egervari | |
|---|---|
| contact affiliation | Washington University School of Medicine |
| contact email | gabor@wustl.edu |
| lab head | |
| Gabor Egervari | |
| contact affiliation | Washington University in Saint Louis |
| contact email | gabor@wustl.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v12/MSV000100736/ |
