PXD074038 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mass Spectrometric Profiling of hepatic GSTM3 - co-immunoprecipitate in Cholesterol-induced Steatohepatic Apoe knockout Mice |
| Description | Glutathione S-transferase Mu 3 (GSTM3) is a cytosolic detoxification isoform of the glutathione S-transferase family, implicated in cellular redox homeostasis and protection against lipid peroxidation–derived reactive products. Emerging evidence suggests that GSTM3 functions beyond xenobiotic metabolism and may contribute to the pathogenesis of stress-induced diseases, including cardiovascular disorders, neurodegenerative diseases, and cancer. However, how the GSTM3-associated interactome links oxidative stress responses to metabolic and inflammatory signaling pathways remains largely unknown. In this study, we performed mass spectrometry–based proteomic profiling of hepatic GSTM3-associated protein complexes using co-immunoprecipitation followed by LC–MS/MS analysis. GSTM3-containing complexes were isolated from the livers of control and cholesterol-induced steatohepatitis Apoe⁻/⁻ mice. The resulting datasets provide an unbiased characterization of the GSTM3 interactome under both basal and disease-associated conditions, enabling the identification of proteins potentially involved in redox regulation, metabolic stress responses, and downstream inflammatory signaling pathways. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-20 |
| AnnouncementXML | Submission_2026-05-20_03:48:01.220.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD074038 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Trina Roy |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-04 00:31:56 | ID requested | |
| ⏵ 1 | 2026-05-20 03:48:01 | announced | |
Publication List
Keyword List
| submitter keyword: ApoE null mice, cholesterol-induced steatohepatitis, liver, Glutathione-s-transferase Mu 3, Orbitrap, Co-immunoprecipitation |
Contact List
| Dr. Arun Bandyopadhyay |
|---|
| contact affiliation | Department of Animal Biotechnology, Gujarat Biotechnology University, Gandhinagar 382355, India; former Professor, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad - 201002, India. Former Director, CSIR-Indian Institute of Chemical Biology, IICB, TRUE Campus, CN-6, Sector 5, Salt Lake, Kolkata 700091, WB, India |
| contact email | arunb2523@gmail.com |
| lab head | |
| Trina Roy |
|---|
| contact affiliation | CSIR-SRF, CSIR - Indian Institute of Chemical Biology |
| contact email | animetrina18@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074038
- Label: PRIDE project
- Name: Mass Spectrometric Profiling of hepatic GSTM3 - co-immunoprecipitate in Cholesterol-induced Steatohepatic Apoe knockout Mice
