⮝ Full datasets listing
PXD073921-1
PXD073921 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Deciphering the RNF114-Mediated Ubiquitin Landscape of TBK1 |
| Description | This project aims to characterize the functional interaction between the E3 ubiquitin ligase RNF114 and the Toll-pathway signaling kinase TBK1 (TANK-binding kinase 1). TBK1 is a central orchestrator of innate antiviral immunity and inflammatory responses. While RNF114 has been implicated in the regulation of immune signaling, the precise molecular "map" of how it modifies TBK1 remains elusive. This study utilizes Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) to identify specific lysine residues on TBK1 that undergo enhanced ubiquitination in the presence of RNF114. |
| HostingRepository | iProX |
| AnnounceDate | 2026-02-02 |
| AnnouncementXML | Submission_2026-02-02_16:40:21.408.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xinguang Lin |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | ubiquitination signature dipeptidyl lysine; methylated residue; phosphorylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-02-02 01:23:30 | ID requested | |
| ⏵ 1 | 2026-02-02 16:40:22 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: RNF114, TBK1, Ubiquitin |
Contact List
| Chuanzhen Zhang | |
|---|---|
| contact affiliation | School of Basic Medical Science, Fudan University |
| contact email | zhangchuanzhen@shaphc.org |
| lab head | |
| Xinguang Lin | |
| contact affiliation | School of Basic Medical Science, Fudan University |
| contact email | 22111010035@m.fudan.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
