PXD073707-1

PXD073707 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis of exosomes derived from human umbilical cord mesenchymal stem cells
Description	Mesenchymal stem cell-derived exosomes (MSC-Exos), noted for their minimal immunogenicity and robust immunomodulatory potential, have emerged as key regulators of immune cell fate. Nevertheless, a comprehensive understanding of their global impact on human NK cell proliferation and effector function remains elusive. In this study, we employed a standardized ex vivo expansion and exosome-priming system to systematically evaluate the regulatory effects of MSC-Exos on peripheral blood-derived NK cells via flow cytometry, cytotoxicity assays, single-cell transcriptomics, and proteomic profiling. Proteomic profiling identified an enrichment of FcγR-related signaling components within MSC-Exos, suggesting a potential role in enhancing antibody-dependent cellular cytotoxicity (ADCC).Collectively, our findings demonstrate that MSC-Exos bolster NK cell expansion and effector maturation through coordinated immuno-metabolic reprogramming, offering a strategic approach to enhancing the therapeutic efficacy of NK cell-based immunotherapies.
HostingRepository	PRIDE
AnnounceDate	2026-04-16
AnnouncementXML	Submission_2026-04-15_23:40:32.973.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bu fanyu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-28 03:12:09	ID requested
⏵ 1	2026-04-15 23:40:33	announced

Dataset with its publication pending

submitter keyword: None

Xuan Dong
contact affiliation	Center for Regeneration and Aging,BGI-haangzhou
contact email	dongxuan@genomics.cna
lab head
Bu fanyu
contact affiliation	15105131523
contact email	bufanyu@genomics.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD073707

PRIDE project URI

• PRIDE
  1. PXD073707
     1. Label: PRIDE project
     2. Name: Proteomics analysis of exosomes derived from human umbilical cord mesenchymal stem cells