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PXD073650-1

PXD073650 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMacrophage SH3GLB1 is required for Rab7-1 mediated mitophagy in inflammation during acute lung injury
DescriptionAcute lung injury (ALI) accompanied by an inflammatory response is an important complication after drowning. Macrophage activation and polarization are implicated in the inflammatory process of lipopolysaccharide (LPS)-induced ALI (LPS-ALI), but little is known about drowning-induced ALI (drowning-ALI). SH3GLB1 is a member of the endophilin family and has been shown to be involved in mitochondrial morphological changes and autophagy. However, its role in ALI remains unclear. Here,we performed single-cell profiling of lung immune cells isolated from the lungs of drowning-ALI mouse models. We found that the regulation of macrophages in drowning-ALI was similar to that in LPS-ALI. Specifically, SH3GLB1 was highly expressed in macrophages of drowning-ALI mouse models and was related to inflammation. Furthermore, SH3GLB1 deletion ameliorated LPS-ALI or drowning-ALI. In contrast, the restoration of SH3GLB1 expression provoked LPS-ALI and drowning-ALI. Mechanistically, SH3GLB1 was shown to interact with Rab7 to contribute to mitophagy, which resulted in mitochondrial dysfunction. Overall, these findings indicated that SH3GLB1 is required for Rab7-mediated mitophagy in inflammation during ALI and could be a novel target for lung protection.
HostingRepositoryPRIDE
AnnounceDate2026-02-10
AnnouncementXMLSubmission_2026-02-09_16:46:48.166.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFa guang Jin
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02026-01-27 10:03:22ID requested
12026-02-09 16:46:48announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Acute lung injury
Drowning
SH3GLB1
Rab7
Mitophagy
Contact List
Fa guang
contact affiliationDepartment of Pulmonary and Critical Care Medicine, Tangdu Hospital, Fourth Military Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an City, Shaanxi Province
contact emailjinfag@fmmu.edu.cn
lab head
Fa guang Jin
contact affiliationFourth Military Medical University
contact emailjinfag@fmmu.edu.cn
dataset submitter
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Dataset FTP location
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PRIDE project URI
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