PXD073643 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Investigation of TOMM6 in brains from Tg2576 mice |
| Description | The protein TOMM6 (translocase of outer mitochondrial membrane 6) was identified as an interacting protein of phospho-S670-GRK2 (G protein-coupled receptor kinase 2 phosphorylated at serine 670) in brain specimens (frontal cortex and hippocampus) of 12-month-old Tg2576 Alzheimer (AD) model mice. Mitochondrial proteins from brain specimens were solubilized and subjected to immuno-affinity enrichment with phospho-S670-GRK2-specific antibodies, which were covalently coupled to Affigel-10. After washing steps to remove unbound proteins, bound proteins were eluted from the immuno-affinity matrix and separated by SDS-PAGE. The immuno-affinity matrix with covalently coupled phospho-S670-GRK2-specific antibodies co-enriched a protein in the range of 6-12 kDa. The protein band was cut out and subjected to identification by nano-LC-ESI-MS/MS. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-16 |
| AnnouncementXML | Submission_2026-02-16_14:23:34.248.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD073643 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Ursula Quitterer |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-01-27 08:43:51 | ID requested | |
| ⏵ 1 | 2026-02-16 14:23:34 | announced | |
Publication List
Keyword List
| submitter keyword: Tg2576 mouse brain, mitochondria |
Contact List
| Ursula Quitterer |
|---|
| contact affiliation | Molecular Pharmacology, ETH Zurich |
| contact email | ursula.quitterer@pharma.ethz.ch |
| lab head | |
| Ursula Quitterer |
|---|
| contact affiliation | ETH Zurich |
| contact email | ursula.quitterer@pharma.ethz.ch |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD073643
- Label: PRIDE project
- Name: Investigation of TOMM6 in brains from Tg2576 mice
