⮝ Full datasets listing
PXD073621-1
PXD073621 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | KMT5A-Mediated Methylation of IRF3 Promotes Tumor Progression through Immune Suppression |
| Description | In the present study, to systematically investigate the post-translational regulatory mechanisms of IRF3 (Interferon Regulatory Factor 3), we conducted comprehensive protein-binding mass spectrometry analysis combined with modification-specific mass spectrometry profiling targeting this key transcription factor. The primary objectives of these experimental approaches were twofold: first, to identify and characterize the potential types of post-translational modifications (PTMs) that IRF3 may undergo—including but not limited to phosphorylation, ubiquitination, acetylation, and sumoylation—and second, to screen for candidate enzymes that are likely to mediate or regulate these modifications, such as kinases, ubiquitin ligases, deacetylases, or SUMO E3 ligases. By integrating data from both protein-protein interaction and PTM profiling, this study aims to provide novel insights into the molecular machinery underlying IRF3’s functional regulation, thereby laying a foundation for further elucidating its role in innate immunity, inflammatory responses, and other pathophysiological processes. |
| HostingRepository | iProX |
| AnnounceDate | 2026-01-27 |
| AnnouncementXML | Submission_2026-01-27_00:19:55.190.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Pengcheng Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-01-27 00:19:22 | ID requested | |
| ⏵ 1 | 2026-01-27 00:19:55 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Mass spectrometry, IRF3 |
Contact List
| Li Sun | |
|---|---|
| contact affiliation | Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology |
| contact email | litchisun@163.com |
| lab head | |
| Pengcheng Li | |
| contact affiliation | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| contact email | 1986438941@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
