PXD073619-1

PXD073619 is an original dataset announced via ProteomeXchange.

Title	The ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis
Description	This study aimed to evaluate the therapeutic effect of ME against UC and to elucidate its underlying molecular mechanism and potential target. ME was semi-synthesized on a gram scale via a biomimetic route. Its activity was assessed in an LPS-induced RAW264.7 macrophage model in vitro and a DSS-induced mouse UC model in vivo. Mechanistic studies employed TMT-based proteomics profiling , an RSL3-induced ferroptosis model, and target identification using DIA-based SPIA proteomics profiling combined with cycloheximide chase and co-immunoprecipitation assays.
HostingRepository	iProX
AnnounceDate	2026-01-27
AnnouncementXML	Submission_2026-01-26_23:38:51.266.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xinye Lv
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X; Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-26 23:38:35	ID requested
⏵ 1	2026-01-26 23:38:51	announced

Dataset with its publication pending

submitter keyword: Maclekarpine E, Inflammation, Ferroptosis, Ulcerative colitis, Ferroptosis inhibitor, OTUD4

Pi Cheng
contact affiliation	Hunan Agricultural University
contact email	picheng55@126.com
lab head
Xinye Lv
contact affiliation	Hunan Agricultural University
contact email	lxyhhh2333@163.com
dataset submitter

iProX dataset URI